Particular protein can make colitis initiate _ general knowledge of cancer of colon

Particular protein can make colitis initiate _ general knowledge of cancer of colon
The scientist knew long ago inflammation was closely linked to cancer, but how on earth is organ inflammation caused the canceration, it is still a mystery. American scientist finds recently, in suffering from mouse's body of experiment of colitis, some particular proteins can touch off a succession of responses, cause cancer of colon finally.

Chronic inflammation closely related to cancer, such as getting easy gastric carcinoma, patient of gastric ulcer, the colitis patient suffers from the risk of cancer of colon and is up to 40, antiinflammatory agent can reduce this kind of risk greatly. Some recent research enables scientist's suspicion, a kind of protein called N F - B may relate to the fact that inflammation touches off the course of cancer.

The molecule biologists of the American branch school in San Diego of University of California Michael and Karin,et al., carry on the test with the experiment mouse which suffers from colitis. Mouse of these experiments is still fed a kind of carcinogen of food intentionally, will suffer from cancer of colon finally basically. The scientist enables some experiment mice lack an enzyme called I K K in the body, these kind of enzyme can irritate the activity of N F - B protein in leather cells on colon, and upper skin cells are exactly the place where cancer of colon is beginning to appear.

As a result, actually must know the experiment mouse which suffered from cancer of colon, only 25 suffered from this disease finally, this reveals that because lacks I K K enzyme to activate N F - B protein, the course of the canceration has been hindered. Relevant achievements are issued on the " cell " magazine of U.S.A. published on the 6th.

The scientist still carries on the test to spinal cells, inhibit the function of I K K enzyme among them, make the cancer morbidity of blood drop 50. Mechanism and difference in the leather cell on the colon in the course this, this indicate I K K enzyme and N F - protein, B of , have two different the intersection of initiation and way of cancer.
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