Specially the sending lung fiber treats the _ treatment of the current situation

Specially the sending lung fiber treats the _ treatment of the current situation
Treat the current situation The treating of IPF still takes glucocorticoid and immune inhibitor medicine as the core at present. Hormone can inhibit inflammation and immune course, may be effective to IPF patient of pathological change that alveolus inflammation is main, but the intersection of quality and fiber it takes issue to be ineffective when being extensive. Further study mechanism that treats IPF of hormone, find it can reduce the quantity of alveolus macrophages and inhibit it from secreting, lying between plain 1 (IL-1 ) in vain , tumour necrosis factor (TNF- ) With transforming growth factor (TGF - ) Wait for the cell factor, can reduce the expression that the big mouse's lung become fibrous cell TGF - 1mRNAs and inhibit its activity [1 ]. However, the clinical materials reveal only hormone of patient less than 30% is valid in treatment [2 ], in addition long-term application hormone and/or obvious side effect that immune inhibitor exists, so use hormone as the regular treatment and remain and have objection to IPF patient. Someone maintain should carry on hormone or complement with the immunity inhibiting to all patient from and treating, can achieve, delay the intersection of lung and fiber take purpose of progress to some patient at least so. But some scholar propose the intersection of IPF and patient correctly, especially old patient, should not routine treat with hormone. Izumi,etc. [3 ], 222 IPF patients in Japan, followed up a case by regular visits to in 10, find that there is not obvious difference compared with hormone therapeutic patient's group in existence quality and limit of the group of patient treated. Up till now, only two prospects, curative effect that random clinical research has been used for commenting on hormone and/or immune inhibitor treats IPF patient for a long time, though jointly use prednisone and sulphur thiazole purine to have certain improvement [4 ] on the patient's life cycle and clinical symptom, but jointly use prednisone and ring phosphorus amide not to observe the same result [5 ]. The experts reach the following common understandings after analyzing the existing clinical materials: The existing therapeutic measure limited to IPF patient's lung function and improvement function of life cycle or has no function. Nowadays used for the medicine curing IPF mostly having a serious side effect. There is no effective therapeutic method [6 ] to IPF yet at present. So, the treatment of IPF remains a severe subject that the clinician faces.
|