Specially therapeutic _'s treatment of the fiber sending lung

Specially therapeutic _'s treatment of the fiber sending lung
It still has disputes to treat that specially taking place lung fiber is the best. The therapeutic purpose is mainly to dispel or inhibit the inflammatory composition. Minority study to show the fiber course is reversible to rotate, but still lack enough evidences.
1,Cortical hormone
Hormone has been specially used for the treatment of the fiber sending lung for already more than 30 years, unfortunately only 10%- 30% of the patients are right to treat effectively, it is rare to totally relieve, even most patients employ the hormone treatment, the condition still worsens. Its dosage and most scholars' opinion of method are:
Hormone employs heavy dose at the time of the initial treatment. Splash the Buddhist nun loose or splash Buddhist nun's loose dragon 40- 80mg/d, 2- 4 months, then the decrement gradually. If the hormone treatment has the response, generally show the result in February - March. Splash the Buddhist nun loose decrement to 30mg/d in the 4th month; The decrement of the 6th month is to 15- 20mg/d (or hormone of other equivalent dosage) . Splashing Buddhist nun's loose consumption and decrement speed should be guided by the clinical or physiologic parameter.
Because it is impossible that hormone totally eliminates disease, so, it is rational in 1- 2 years by minimum dose treatment to treating the patient having various reactions. It is already enough to employ and splash the Buddhist nun loose 15- 20mg/d and keep treating as being low dose of for a long time. Employ heavy dose of first to splash nylon (1- 2g, once or 2 times of every week) The vein is " assaulted" Treat, but is not superior to oral hormone.
The patient failing to the hormone treatment, add and use sulphur thiazole purine (AZP) Or the ring phosphorus amide (CTX) ,And stop using hormone decrement in 4- 6 weeks. As hormone at the decrement, some the intersection of patient and condition develop or worsen, can oral administration splash Buddhist nun to be loose (20- 40mg) every other day to patient these ,In addition add and use the immune inhibitor or malicious medicine of cell.
2,Therapeutic method recommended at present
Have not proved yet which propose adding sulphur thiazole purine or ring phosphorus amide with hormone under the best situation of therapeutic method, patient that better for the possible result of expectancy.
Hormone: Initial therapeutic method, use and splash the Buddhist nun loose (or hormone of the other equivalent dosage) 0.5mg/ (kg d) (ideal weight, IaqM) ,Take orally for 4 weeks; Then 0.25mg/ (kg d) (133M) ,Take orally for 8 weeks; Decrement to 0.125mg/ (kg d) continued Or 0.25mg/kg, once every other day.
Sulphur thiazole purine: 2- 3mg/(kg d) (LBM) ,Take orally, initial dosage 25-50mg/d, increase 25mg 7- 14 day while being every, until maximum dose 150mg/d. Or the ring phosphorus amide: 2mg/(kg d) (LBM) Take orally, initial dosage 25-50mg/d, increase 25mg 7- 14 day while being every, until maximum dose 150mg/d.
If there is no side effect or complication to appear, should treat for at least 6 months continuously. Should observe and treat and react during this period. Should pay attention to monitoring the medicine side effect, with the minimum dosage, minimum side effect as much as possible, reach the best curative effect.
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