Specially sending fiber _'s general knowledge of reason of lung

Specially sending fiber _'s general knowledge of reason of lung
Specially from what reason was the sending lung fiber caused?
The cause of disease of this disease has not been bright, the quality among the disseminated lung fiber is limited to the lung. Hamman and Rich reported several at first in 1935 and 1944 respectively, it was acute type, developed sharply, die from 6 weeks to half a year, so have another name called Hamman-Rich syndrome. This disease have illness coming on at 40-50 years old more, men exceed women slightly, spread all over disease in whole world, morbidity and case fatality rate are all raised in the past 10 years, the overwhelming majority is chronic type, the higher age of onset is, the longer the course of disease is. Acute type and rare. Most scholars think department's one's own immune disease, may relate to inherent cause in recent years.
IPF cause of disease is not clear, mechanism has not also totally expounded the onset, but already enough evidences have indicated to relate to the fact that immune inflammation has been damaged. The inflammatory response characteristic of immunity that different samples reveal is not the same, what the blood around reflected is that immunity is unusual more outstanding, and the bronchus alveolus irritates lotion to reveal inflammation reacts for the main fact, and the abnormal state of lung local organization is different to some extent. So it studies materials to need to consider this kind of difference to assess various.
Synthesize the research in recent years, have illness coming on about IPF mechanism and course summarize as follows:
A certain unknown antigen activates B cells, produce Ig and and form the immune complex, and then stimulate and activate alveolus macrophages. This immunoreaction is some in the lung, if alveolus wall B lymphocytes produced antibodies, then some compositions of the alveolus wall may be discerned as foreign matter wrongly. So someone thinks IPF can be regarded as one's own immune disease. But change and function of IPF patient T cells are indeterminate, only B cells are participated in not enough to prove it as one's own immune disease.
Activatory alveolus macrophages release many kinds of mediums, damage structure such as the ground substance, basilar membrane of lung cells, cells directly except protein hydrolase, collagenase, reactive oxygen supersession product and some cell factors, still there is medium including fiber that is formed and closely related with with the fiber that connects albumens (fibronectin, FN) , the original growth factor (alveolar macrophage derived growth factor, AMDGF) of macrophage of alveolus , the blood platelet derives growth factor (platelet derivedgrowth factor, PDGF) With one kind of growth factors(insulinlike growth factor, IGF) of insulin Wait, they can absorb into fibrous cells, and stimulate its hyperplasia, and lie between and lead the collagenic ground substance to shrink.
IL-8, TNF,etc. released in alveolus macrophages lie between, lead, lay neutral cells to hasten and melt, assemble and activate towards the alveolus, form and increase by neutral grains of cell rate (20%) It is alveolus inflammation of the characteristic, and neutral grains of cell inflammation react and release a series of medium again, cause or aggravate the lung to damage with the fiber.
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