Specially sending fiber physiological _'s general knowledge of pathology of lung

Specially sending fiber physiological _'s general knowledge of pathology of lung
Living histology of examining sample of the lung is very important to getting rid of other diagnosis and quantification of fiber and inflammatory intensity. Quality) among the main pathological characteristic of IPF includes the interval of alveolus ' With fiber and inflammation of the alveolus at various degrees. Because there can be similar manifestation in a lot of inflammation lung diseases, must get rid of granulation swollen, vascular inflammation, inorganic lung dust calm ill or organic lung dust calm disease. It is varied that the pathology of IPF changes, and take the form of slice and is distributed, lie in the periphery of lung (under pleura) more . Even the lobe of the lung in the serious pathological change, some alveoluses can also avoid being given much trouble. Unless at disease early period, can keep alveolus structure intact,but increase alveolus wall edema thick, among assemble inflammatory cell at quality, take monocyte as the core (such as lymphocyte, plasma cell, monocyte, macrophage) ,But can be seen scatteredly in the neutral cells of core and acidophil.
The intersection of disease and early period stage, it is obvious alveolus macrophage present cooking stove gathering, scarce macrophage such as in the issues of alveolus of IPF. Develop with disease, chronic inflammation does not soak more and more obvious, the alveolus structure is replaced by the dense fibrous tissue, the alveolus wall ruptures and destroys, cause the bag expansion (honeycomb lung) of angry way .
The later period of disease, a large number of lung collagen, cell inner ground substance in the quality among the lung, becoming there are few even scarce fibrous cell, inflammatory cell like. Course of disease relatively elder, it is obvious leather hyperplasia, scale grow at the alveolus. The reactive hyperplasia of smooth muscle can take place to some patients, lung arteriectasis, continue taking place artery high pressure of lung,etc. to change. The angry way can be twisted and deformed, cause " pulling bronchiectasis " . IPF patient substantially as smoking can see pulmonary emphysema to change.
Whether to have fibers according to the honeycomb bag or not to organize distinguishing pulmonary emphysema and honeycomb lung. The filling the air alveolus damages the characteristic that is not early IPF, can be seen at a lot of other lung diseases too, if the adult breathes poverty-stricken syndrome (ARDS) , sucking lung damaging, radioactive lung damaging, medicine lung damaging, collagen vascular disease, infecting,etc..
Have divided IPF into several pieces of inferior type pathology subjectively, has thought that takes off quality pneumonia (DIP) among the bits With quality pneumonia (UIP) among the general type It is a pathologic type at stage of IPF different courses of disease. And learn (ATS) according to the American division of chest disease Breathe and learn (ERS) with Europe The diagnosis to IPF has put forward the brand-new international common understanding: The peculiar pathology of summing up UIP as IPF behaves, and DIP, breathing bronchitis pulmonary tuberculosis (RBILD) , it is not quality pneumonia (NSIP) among the specificity Quality pneumonia (LIP) among being lymphocytic and cellulous , acute rooms of quality pneumonia (AIP) , stopping up thin bronchitis and accompanying machine pneumonia (BOOP) It is not IPF.
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