Issue Fudan University and find the research results which treats the new route of common cerebroma

>Issue Fudan University and find the research results which treats the new route of common cerebroma
Account for the common malignant tumours of 40% of tumour in all craniums - --Neuroglia tumour, it is expected to find the new treatment. Fudan University announces on April 12, a seminar which regards graduate student under grade three as main strength is only in half years, analyse and explain the difficult problem during the keen competition of international scientific research at first, find the canceration molecule mechanism and find and inhibit the composition. 10 days of April, international top academy periodical >Have issued this important achievement, and specially publish a concerted comments, highly comment on.
There are gliomas " L Three Senior One is low " R Characteristic - --Morbidity, rate of recuring, mortality are high, but the cure rate is low. Because glioma belongs to and invades moist growth, does not have obvious boundary with the brain tissue, it is difficult to all excise, can't be cured effectively through the traditional operation. Meanwhile, existing the intersection of tumour and medicine and radiotherapy direct against more growth period cell, be cancer cell to be powerless to in resting state glioma. At present, it doesn't obtain breakthrough development all the time to invade the moist extremely strong glioma treatment.
It is introduced, the American scientist was here last October>The magazine publishes the thesis, find the malignant colloid tumour has genes that mutation takes place in one " IDH1" ,This conclusion is verified in a large number of tumour samples in a plurality of laboratories in the whole world rapidly. Studies have suggested, the mutation probability in continuing taking place glioma of IDH1 gene mutation reaches more than 75% high, probably IDH1 gene will be glioma potential making a diagnosis indicator and target. But realize the key from target to treatment is to find how IDH1 gene mutation promotes tumour to grow, this molecule mechanism is exactly the difficult problem that the biomedical molecule cell biology research office of research institute of Fudan University analyses and explains this time.
This difficult problem was put in front of the scientific research personnel in whole world, seminars of various countries raced against time and launched research. Formal the intersection of operation and less than 3 the intersection of Fudan University and the intersection of molecule and cell biology research office of year, Yue Xiong, in charge of female good, ShiMin, the intersection of thunder and groups of the intersection of Great Britain and 4 Mr. Zhao, and 15 graduate students and several technological administrative staff, mean age is only 30 years old. This group focuses on " IDH1 gene " R Tackle key problems, find the responses of a bunch of dominoes types on the molecule aspect of cell, it seems that growing for tumour cells steps on a kick throttle.
After the molecule mechanism is clear, researchers " L Suit the remedy to the case " R Again then find: A kind of internal metabolite " KG analog " R It seems that a set of systems of braking, can inhibit tumour cells from increasing effectively. The expert introduces, this kind " KG analog " Improve metabolite in it is it have cell one's more own since human body,may side effects nonpoisonous and last phenomenon, extremely apt to enter cells, it is expected to be used in clinic comparatively fast.
It is reported, this subject is finished smoothly within 6 months, and contribution >Magazine . This international authoritative publication is fast within 4 weeks too to finish first instance and second instance to the thesis, and select in the cancer research association the 100th of U.S.A. specially A conference issued shortly before holding.
>Allot commenting that is thought: This achievement, to announcing the gene mutation molecule mechanism of glioma has initiative meanings, " KG analog " Contain function on many other tumour growth including glioma, have developed and found a new way for the clinical tumour medicine.
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