A gene is lacked or aggravated the alcohol liver to damage

A gene is lacked or aggravated the alcohol liver to damage
It is reported ' Reporter Hu DeRong) The scientific research personnel of scientific research institute of nutrition of research institute of Shanghai life of Chinese Academy of Sciences have announced function in the liver of smad7 gene recently and damaged in the alcohol liver The function of China, has established the theoretical foundation in order to look for and intervene alcohol the measure causing the liver to damage effectively. Thesis of this research was in U.S.A.'s academic periodical a few days ago >The magazine issued online .
It will influence the fat supersession of liver to drink in a large amount for a long time, cause fatty liver and more serious liver disease. The research has suggested, adjust and control the factor as tgf - defeat of 's signal thorough fare, smad7 has a plurality of important biological functions, but the rare report at present of function in the alcohol liver is damaged.
Scientific research personnel find behind the little mouse model of smad7 in succeed in, construct, build the liver cell specificity in, knock at, except that the striking of smad7 has strengthened tgf-beta signal thorough fare in liver cells peculiarly, some little mice demonstrate spontaneous liver function is damaged. The alcohol diet of the time is induced through lasting 6 weeks to the little mouse, compared with control group, it strike smad7 gene except that demonstrate mouse more serious liver function damaging and alcohol fatty liver.
Further discover, under the intersection of alcohol and stimulus of diet, smad7 gene strike, get rid of the intersection of alcohol and key the intersection of enzyme and ethanol of supersession take off hydrogen enzyme expression amount of adh-1 apparent to lower than control group in the little the intersection of mouse and liver, and synthetic expression of relevant gene and many kinds of inflammation factor of the fat is apparent increase. These discoveries brief on, smad7 gene can change the supersession route in the human body of alcohol to lack, and influenced lipoprotein metabolic disorder and inflammation to react.
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