First breast cancer restrains the cancer gene and is found newly

First breast cancer restrains the cancer gene and is found newly
It is reported ' Cloud of Great Britain of Rui Lin Chen of Joe of clothing dawn peak reporter of the reporter) Top magazine of world>Issued the medical college of Harvard University and expert in Harbin medical university about ptpn12 recently The albumen is a new result of study of restraining the cancer gene. This restrains the cancer gene to sift, check that studies to what the third overcast breast cancer is carried on, to three overcast the intersection of breast cancer and to treat great directive significance target.>The magazine has been specially commented to this thesis .
It is introduced ptpn12 whether laboratory, elledge of Harvard Medical School, screen the intersection of tumour and the intersection of cell and first positive the intersection of albumen and member that find transform factor, with the intersection of shrna and the intersection of library and technology. Discover, ptpn12 will cause normal cells to be malignant and grow while expressing competence and reducing, can grow, have, inhibit the result from while being sure to malignant cell while being excessive to express. Through to the intersection of ptpn12 and the intersection of albumen and the intersection of functional domain and analysis of structure, expert determine the nature it whether one hold amino acid in place with a net, go enzyme phosphorylase.
In order to further announce restraining the cancer mechanism of ptpn12, Kazakhstan the intersection of water and Professor utilize front quantify phosphorylated the intersection of albumen and group, learn, discover by technology in the world at present medical will it be spring week such as research room such as science of heredity such as medical university, when ptpn12 expresses and inhibited, urging cancer genetic egfr to hold the phosphorylation of amino acid in place with a net by the body family apparently to strengthen of breast cancer. And the intersection of egfr and the intersection of receptor and family hold the phosphorylation of amino acid in place with a net and is activated while being a series of just, thus produced and urged the cell canceration effect. Point out egfr,etc. and urge the cancer gene to be target some albumen molecules of internal function of ptpn12 in Zhou ChunShui's research, have succeeded in locking ptpn12 It is a new kind of that restrains cancer gene.
Researcher of Harvard Medical School discover ptpn12 have lacking gene mutation of functions in many kinds of three overcast the intersection of breast cancer and the intersection of cell and department further. In three overcast breast cancer patient's sample pathologic section of clinic in 60%, ptpn12 albumen expressed low. Clinical the intersection of case and result of study these support ptpn12 occupy the important status in three overcast emergence progress course of breast cancer further.
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