A improvement heart declines the experimental medicine _'s treatment of symptom

A improvement heart declines the experimental medicine _'s treatment of symptom
Summary: An experimental medicine can improve symptom of the congestive patient in heart failure. (The New England Journal of Medicine 2000; 343:246-253.)
New York, July 27 (Reuter's medical news) According to researcher: An experimental medicine can improve symptom of the congestive patient in heart failure. Congestive and in heart failure (CHF) And presents a kind of state that the pump blood efficiency reduces for the cardiac enlargent. Its symptom includes feeling suffocated, four limbs edema and fatigue. Wilson S of the medical center of Boston University of Massachusetts state. A research group of Dr. Colucci leader's, is called nesiritide (Natrecor) to one kind Carrying on by research, use for not the impatienting of CHF symptom the medicine. This medicine has not made the approval of American FDA yet, it is exactly the same as a kind of protein that has been produced of heart, can relax the muscles of the artery tube wall. Through reducing the resistance of blood flow, thus reduce the working load of heart.
Researcher carry on two single experiment in nesiritide to all 432 because of the intersection of CHF and patient in hospital. A group of patients accept the drug therapy of the high or low dosage, the control group uses placeboes (excluding tablet of nesiritide) ; Another group of experiments is used in the medicine curing CHF to nesiritide and conventionally and carry on the direct contrast.
Compared with placebo, nesiritide has more prominent results on lightening CHF symptom. On the whole, 60%-67% of the patient using nesiritide in two groups of experiments feel the symptom improve, and the patient who take placebo only has 14% to feel the symptom is improved. The patient has about halves feel suffocated symptom is improved to use medicine, and only have 12% with the placebo patient. Use medicine group patient tired to lighten as 32% - 38%, placebo group 5% only. The report of Colucci group issued the medical magazine of New England published on July 27 Have.
They point out in the report, in the test that nesiritide compares with other medicines, the experiment treats progress well. All treatments have similar function on the patient's whole body states and tired symptoms feeling suffocated. In the patient who takes nesiritide, the side effect of hypotension is relatively common, but this kind of side effect is often slight or does not produce any symptom.
Dr. Colucci and his colleague declare: "Our experiment has proved nesiritide can be lightened and lost the compensating congestive symptom in heart failure. " They say this kind of medicine is to CHF, especially severe all humoral patients staying may be effective, patient take behind the medicine this needing the intersection of diuresis and medicine come, increase urine quantity in order to humoral to get rid of too much one no longer nearly.
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